Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate
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چکیده
منابع مشابه
Maternal MTHFR genotype contributes to the risk of non-syndromic cleft lip and palate.
Recently, we reported a whole genome scan in sib pairs with non-syndromic cleft lip and palate (CLP), highlighting several regions as possible susceptibility loci, one of which is situated on 1p36. This region is of particular interest in CLP as it harbours the gene encoding MTHFR, an enzyme fundamental in the metabolism of the biologically active form of folic acid. Dietary folic acid deficien...
متن کاملGenetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts.
Clefts of the lip and/or palate (CL/P) are among the most common birth defects worldwide. The majority are non-syndromic where CL/P occurs in isolation of other phenotypes. Where one or more additional features are involved, clefts are referred to as syndromic. Collectively CL/P has a major clinical impact requiring surgical, dental, orthodontic, speech, hearing and psychological treatments or ...
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Introduction: Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate. Materials and Methods: We conducted a case control study at the Women’s Hospital in Culiacan...
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This article has no abstract.
متن کاملMaternal 677CT/1298AC genotype of the MTHFR gene as a risk factor for cleft lip.
Non-syndromic cleft lip with or without cleft palate (CL/P) is one of the most common congenital anomalies world wide. It has a prevalence of approximately 1/1000 among white populations and 1/600 among Thai newborns. Environmental and genetic factors have been implicated in CL/P and several different loci and genes have been associated with them. Maternal folic acid supplementation during earl...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2002
ISSN: 1468-6244
DOI: 10.1136/jmg.39.5.368